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miRNAs and Cancer
Event Date: February 20, 2008 12:00 Noon Eastern Standard Time; 9:00 a.m. Pacific Standard Time
Brought to you by the Science/AAAS Business Office
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microRNAs (miRNAs) play critical roles in developmental and physiological processes by regulating target gene expression at the post-transcriptional level. It is therefore not surprising that deregulation or dysregulation of miRNA expression could result in specific disease phenotypes. Increased interest in the function of miRNAs in tumor initiation and progression has rapidly propelled research forward as new technologies, or the adaptation of old technologies, has allowed researchers to screen both more broadly and more specifically for aberrant miRNA expression in cancers.
This webinar will focus on some key cancer-related miRNAs currently under investigation, as well as methods for detection and characterization of miRNAs, particularly those suspected to be involved in tumorigenesis. Progress towards the development of possible cancer biomarkers will be discussed, as will problems and hurdles that miRNA researchers might encounter and how to overcome them.
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Speakers:
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George A. Calin, M.D., Ph.D.
George Adrian Calin received both his M.D. and Ph.D. degrees at Carol Davila University of Medicine in Bucharest, Romania. After working cytogenetics as undergraduate student with Dragos Stefanescu in Bucharest, he completed his cancer genomics training in Massimo Negrini’s laboratory at University of Ferrara, Italy. In 2000 he became a postdoctoral fellow at Kimmel Cancer Center in Philadelphia, PA, in Carlo Croce’s laboratory. He is presently an Associate Professor in Experimental Therapeutics at MD Anderson Cancer Center and studies the roles of microRNAs and other noncoding RNAs in cancer initiation and progression, as well as the mechanisms of cancer predisposition, and explores new RNA therapeutic options for cancer patients.
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Frank Slack, Ph.D.
Frank Slack received his B.Sc. from the University of Cape Town in South Africa, before completing his Ph.D. in molecular biology at Tufts University School of Medicine. He started work on microRNAs as a postdoctoral fellow in Gary Ruvkun’s laboratory at Harvard Medical School, where he codiscovered the second known microRNA, let-7. He is currently an Associate Professor in the Department of Molecular, Cellular and Developmental Biology at Yale University. The Slack laboratory studies the roles of microRNAs and their targets in development and disease, particularly cancer. |
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Scott M. Hammond, Ph.D.
Scott Hammond obtained his Ph.D. in Molecular and Cellular Pharmacology from the State University of New York at Stony Brook. He received postdoctoral training in the lab of Gregory Hannon at Cold Spring Harbor, New York. He
is currently an Assistant Professor at the University of North Carolina, Chapel Hill. His research specializes in small RNA biology and its contribution to disease. He has made groundbreaking discoveries on the role of microRNAs in the pathogenesis of cancer.
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Moderator: Sean Sanders, Ph.D., Commercial Editor, Science/AAAS
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Sean Sanders did his undergraduate training at the University of Cape Town, South Africa, and his Ph.D. under Sir Dillwyn Williams at the University of Cambridge, UK, supported by the Wellcome Trust. Following postdoctoral training at the National Institutes of Health and Georgetown University, Dr. Sanders joined TranXenoGen, a startup biotechnology company in Massachusetts working on avian transgenics. Pursuing his parallel passion for writing and editing, Dr. Sanders joined BioTechniques as an editor in 2004 before recently taking the position of Commercial Editor at Science/AAAS.
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